Skeletal Muscle Relaxants: Directly acting – other

QUININE

Quinine is an antipyretic and antimalarial; also sometimes used in treating lupus and arthritis The following are the reasons for quinine appearing under “Skeletal Muscle Relaxants”

1. Quinine was used to relieve nocturnal leg cramps in recent past; now this use has been strongly warned against by the FDA

2. When directly injected into a nerve, it causes paralysis of muscle by direct action on the muscle

3. It has been show to ↑ refractory period and ↓ motor excitation at motor end-plate; the response of the muscle ↓ when exposed to repetitive neural stimulation

4. it has been shown to ↓ muscle tone in myotonia congenita and myotonic dystrophy

Reference: “Mechanism of action of Quinine in myotonia and myasthenia”; A.M Harvey; Journal of the American Medical Association 1939;112(16):1562-1563.

 HAPPY HOLIDAYS AND SEE YOU IN THE NEW YEAR!

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

w

Connecting to %s