Skeletal Muscle Relaxants: Dual action – our molecules

BENZOQUINONIUM

1. Benzoquinonium has curare-like relaxing action that is only only weakly antagonized by neostigmine

2. Excreted unchanged in urine; causes bradycardia; ↑ bronchial and salivary secretions

3. Has unwanted muscarinic side-effects and its relaxant action is not countered by neostigmine

Use as surgical adjuvant: ABANDONED

 

Reference: Progress in Medicinal Chemistry, Volume 2; editors: Gwynn Pennant Ellis, Geoffrey Buckle West; Butterworth-Heinemann, 2011.

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